Intricate Connections between the Microbiota and Endometriosis
| Autor: | Mohamed A. Bedaiwy, Irene Jiang, Paul J. Yong, Catherine Allaire |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
endometriosis uterine microbiota QH301-705.5 Endometriosis Review Biology Gut flora medicine.disease_cause antibiotics Catalysis Proinflammatory cytokine Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Immune system immune dysregulation Lactobacillus estrobolome medicine microbiota estrogen Humans Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy vaginal microbiota 030219 obstetrics & reproductive medicine gut microbiota Organic Chemistry General Medicine dysbiosis Immune dysregulation biology.organism_classification medicine.disease Computer Science Applications Immunosurveillance Chemistry 030104 developmental biology probiotics inflammation Immunology Female metabolome Dysbiosis |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5644, p 5644 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Imbalances in gut and reproductive tract microbiota composition, known as dysbiosis, disrupt normal immune function, leading to the elevation of proinflammatory cytokines, compromised immunosurveillance and altered immune cell profiles, all of which may contribute to the pathogenesis of endometriosis. Over time, this immune dysregulation can progress into a chronic state of inflammation, creating an environment conducive to increased adhesion and angiogenesis, which may drive the vicious cycle of endometriosis onset and progression. Recent studies have demonstrated both the ability of endometriosis to induce microbiota changes, and the ability of antibiotics to treat endometriosis. Endometriotic microbiotas have been consistently associated with diminished Lactobacillus dominance, as well as the elevated abundance of bacterial vaginosis-related bacteria and other opportunistic pathogens. Possible explanations for the implications of dysbiosis in endometriosis include the Bacterial Contamination Theory and immune activation, cytokine-impaired gut function, altered estrogen metabolism and signaling, and aberrant progenitor and stem-cell homeostasis. Although preliminary, antibiotic and probiotic treatments have demonstrated efficacy in treating endometriosis, and female reproductive tract (FRT) microbiota sampling has successfully predicted disease risk and stage. Future research should aim to characterize the “core” upper FRT microbiota and elucidate mechanisms behind the relationship between the microbiota and endometriosis. |
| Databáze: | OpenAIRE |
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