Quantitative Motion Measurements Based on Markerless 3D Full-Body Tracking in Children with SMA Highly Correlate with Standardized Motor Assessments
| Autor: | Andreas Schroeder, Florian Heinen, Katharina Vill, B. Warken, Claudia Hodek, Nikolas Hesse, Therese Well, Wolfgang Müller-Felber, Astrid Blaschek |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diagnostic Techniques Neurological Motor Activity 030105 genetics & heredity Proof of Concept Study Motion capture Standard deviation Motion (physics) Muscular Atrophy Spinal 03 medical and health sciences symbols.namesake 0302 clinical medicine Physical medicine and rehabilitation Match moving medicine Humans 030212 general & internal medicine business.industry Infant Spinal muscular atrophy medicine.disease SMA Trunk Pearson product-moment correlation coefficient Biomechanical Phenomena Neurology Child Preschool symbols Neurology (clinical) business Psychomotor Performance |
| Zdroj: | Journal of Neuromuscular Diseases. 9:121-128 |
| ISSN: | 2214-3602 2214-3599 |
| DOI: | 10.3233/jnd-200619 |
| Popis: | Background: Spinal Muscular Atrophy (SMA) is the most common neurodegenerative disease in childhood. New therapeutic interventions have been developed to interrupt rapid motor deterioration. The current standard of clinical evaluation for severely weak infants is the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND), originally developed for SMA type 1. This test however, remains subjective and requires extensive training to be performed reliably. Objective: Proof of principle of the motion tracking method for capturing complex movement patterns in ten children with SMA. Methods: We have developed a system for tracking full-body motion in infants (KineMAT) using a commercially available, low-cost RGB-depth sensor. Ten patients with SMA (2–46 months of age; CHOP INTEND score 10–50) were recorded for 2 minutes during unperturbed spontaneous whole-body activity. Five predefined motion parameters representing 56 degrees of freedom of upper, lower extremities and trunk joints were correlated with CHOP INTEND scores using Pearson product momentum correlation (r). Test-retest analysis in two patients used descriptive statistics. Results: 4/5 preselected motion parameters highly correlated with CHOP INTEND: 1. Standard deviation of joint angles (r = 0.959, test-retest range 1.3–1.9%), 2. Standard deviation of joint position (r = 0.933, test-retest range 2.9%), 3. Absolute distance of hand/foot travelled (r = 0.937, test-retest range 6–10.5%), 4. Absolute distance of hand/foot travelled against gravity (r = 0.923; test-retest range 4.8–8.5%). Conclusions: Markerless whole-body motion capture using the KineMAT proved to objectively capture motor performance in infants and children with SMA across different severity and ages. |
| Databáze: | OpenAIRE |
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