Epidemiology of acute febrile illness in Latin America
Autor: | Clarisse da Silveira Bressan, André Siqueira, Patrícia Brasil, José Cláudio Fonseca Moreira |
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Rok vydání: | 2018 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Fever 030231 tropical medicine Context (language use) Dengue virus medicine.disease_cause Article Dengue fever Zika virus Dengue 03 medical and health sciences 0302 clinical medicine Environmental health Epidemiology Prevalence Humans Medicine Hospital Mortality 030212 general & internal medicine Chikungunya Geography Medical biology Coinfection Acute febrile illness business.industry General Medicine medicine.disease biology.organism_classification Co-infection Malaria Latin America Infectious Diseases Population Surveillance Acute Disease Etiology business |
Zdroj: | Clinical Microbiology and Infection |
ISSN: | 1198-743X |
Popis: | Background The causes of acute febrile illness (AFI) in Latin America are diverse and their complexity increases as the proportion of fever due to malaria decreases, as malaria control measures and new pathogens emerge in the region. In this context, it is important to shed light on the gaps in the epidemiological characteristics and the geographic range for many AFI aetiologies. Objectives To review studies on community-acquired fever aetiology other than malaria in Latin America, and to highlight knowledge gaps and challenges needing further investigation. Sources PubMed from 2012 to April 2018. Content We found 17 eligible studies describing 13 539 patients. The median number of pathogens tested per individual was 3.5 (range 2–17). A causative pathogen could be determined for 6661 (49.2%) individuals. The most frequently reported pathogen during the study periods was dengue virus (DENV) (14 studies), followed by chikungunya virus (nine studies) and Zika virus (seven studies). Among the studies reporting concurrent infections, 296 individuals (2.2%) were found to have co-infections. In-hospital mortality was reported in eight (47%) studies, ranging between 0% and 18%. Implications DENV fever is the febrile illness most frequently reported, reflecting its importance, while chikungunya and zika viruses present increasing trends since their emergence in the region. Studies with systematic and harmonized approaches for detection of multiple pathogens are needed and would probably reveal a higher burden of neglected pathogens such as Rickettsia spp. and arenaviruses. The lack of point-of-care tests and harmonized approach limits the care provided by health professionals and the efficacy of surveillance for AFI in the region. |
Databáze: | OpenAIRE |
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