Age-dependent regional changes in the rostral migratory stream
| Autor: | Jessica H. Brann, Marion Richard, Stuart Firestein, Alex K. Bryant, Charles A. Greer, Arie S. Mobley |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Aging
Interneuron genetic structures Rostral migratory stream Neurogenesis Subventricular zone Biology Article Cerebral Ventricles Mice Neuroblast Cell Movement medicine Animals Cell Proliferation Neuroblast proliferation General Neuroscience musculoskeletal neural and ocular physiology Olfactory Bulb Olfactory bulb Mice Inbred C57BL medicine.anatomical_structure Cytoarchitecture nervous system Neurology (clinical) Geriatrics and Gerontology Neuroscience Developmental Biology |
| Zdroj: | Neurobiology of aging. 34(7) |
| ISSN: | 1558-1497 |
| Popis: | Throughout life the subventricular zone (SVZ) is a source of new olfactory bulb (OB) interneurons. From the SVZ, neuroblasts migrate tangentially through the rostral migratory stream (RMS), a restricted route approximately 5 mm long in mice, reaching the OB within 10e14 days. Within the OB, neuroblasts migrate radially to the granule and glomerular layers where they differentiate into granule and periglomerular (PG) cells and integrate into existing synaptic circuits. SVZ neurogenesis decreases with age, and might be a factor in age-related olfactory deficits. However, the effect of aging on the RMS and on the differentiation of interneuron subpopulations remains poorly understood. Here, we examine RMS cytoarchitecture, neuroblast proliferation and clearance from the RMS, and PG cell subpopulations at 6, 12, 18, and 23 months of age. We find that aging affects the area occupied by newly generated cells within the RMS and regional proliferation, and the clearance of neuroblasts from the RMS and PG cell subpopulations and distribution remain stable. |
| Databáze: | OpenAIRE |
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