Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats
| Autor: | Hanh Thuy Nguyen, Hyoung Geun Park, Jong Oh Kim, Jae Young Yu, Chul Soon Yong, Joon Ho Jun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty hepatic triglyceride Alcohol Hangovers 03 medical and health sciences chemistry.chemical_compound Liver disease Morning careê Internal medicine medicine Ethanol metabolism lcsh:QH301-705.5 lcsh:R5-920 Triglyceride business.industry Acetaldehyde alcohol-induced fatty liver medicine.disease 030104 developmental biology Endocrinology chemistry hangover lcsh:Biology (General) Alcoholic fatty liver Liver function business lcsh:Medicine (General) acetaldehyde |
| Zdroj: | Laboratory Animal Research, Vol 34, Iss 2, Pp 49-57 (2018) |
| ISSN: | 2233-7660 |
| DOI: | 10.5625/lar.2018.34.2.49 |
| Popis: | Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning careê Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyungê and Ukonê). The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. Serum liver function markers (aspartate and alanine aminotransferase activities) and serum/liver lipid levels were assessed. Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyungê, as compared with control rats. However, Ukonê did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation. These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver. |
| Databáze: | OpenAIRE |
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