Preparation of Neurotensin Analogue-Containing Poly(dl-lactic acid) Microspheres Formed by Oil-in-Water Solvent Evaporation
| Autor: | Sumio Watanabe, Ichiro Yamakawa, Ryoichi Machida, Yuki Tsushima |
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| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
Chromatography Polymers Polyesters Molecular Sequence Data Pharmaceutical Science Fatty acid Salt (chemistry) Polymer Microspheres Peptide Fragments Dosage form Lactic acid Solvent chemistry.chemical_compound chemistry Phase (matter) Lactates Solvents Amino Acid Sequence Lactic Acid Oligopeptides Neurotensin |
| Zdroj: | Journal of Pharmaceutical Sciences. 81:899-903 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600810912 |
| Popis: | This report describes the preparation of injectable microspheres containing a neurotensin analogue (NA), which is a hexapeptide with neurotensin activity. NA, a hydrophilic drug, was successfully entrapped into poly( dl -lactic acid) microspheres prepared by a novel oil-in-water solvent evaporation method. The preparation method was investigated with regard to the partition of NA into the oily phase and the rapid phase separation of the polymer. Successful entrapment was achieved with the following conditions: (1) an alkaline water phase, (2) addition of fatty acid salt in the oily phase, and (3) addition of a water-miscible solvent in the oily phase. Under these conditions, NA was completely entrapped into the microspheres at poly( dl -lactic acid):NA molar ratios of >3. |
| Databáze: | OpenAIRE |
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