Immune System Modifications Induced in a Mouse Model of Chronic Exposure to (90)Sr
| Autor: | Olivia Delissen, Johanna Stefani, Nicholas Synhaeve, Jean-Marc Bertho, Isabelle Dublineau, Nour Nicolas, Stefania Musilli |
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| Přispěvatelé: | PRP-HOM/SRBE/LRTOX, Institut de Radioprotection et de Sûreté Nucléaire (IRSN) |
| Rok vydání: | 2016 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Biophysics Spleen medicine.disease_cause CD19 030218 nuclear medicine & medical imaging 03 medical and health sciences Mice 0302 clinical medicine Immune system Antigen medicine Ingestion Animals Humans Radiology Nuclear Medicine and imaging B-Lymphocytes Radiation biology Toxin Radiation Exposure 3. Good health Disease Models Animal medicine.anatomical_structure 13. Climate action 030220 oncology & carcinogenesis Immune System Immunology biology.protein Strontium Radioisotopes Bone marrow Keyhole limpet hemocyanin |
| Zdroj: | Radiation Research Radiation Research, 2016, 185 (3), pp.267-284. ⟨10.1667/RR14014.1⟩ |
| ISSN: | 1938-5404 0033-7587 |
| DOI: | 10.1667/RR14014.1⟩ |
| Popis: | International audience; Strontium 90 (90Sr) remains in the environment long after a major nuclear disaster occurs. As a result, populations living on contaminated land are potentially exposed to daily ingesting of low quantities of 90Sr. The potential long-term health effects of such chronic contamination are unknown. In this study, we used a mouse model to evaluate the effects of 90Sr ingestion on the immune system, the animals were chronically exposed to 90Sr in drinking water at a concentration of 20 kBq/l, for a daily ingestion of 80-100 Bq/day. This resulted in a reduced number of CD19+ B lymphocytes in the bone marrow and spleen in steady-state conditions. In contrast, the results from a vaccine experiment performed as a functional test of the immune system showed that in response to T-dependent antigens, there was a reduction in IgG specific to tetanus toxin (TT), a balanced Th1/Th2 response inducer antigen, but not to keyhole limpet hemocyanin (KLH), a strong Th2 response inducer antigen. This was accompanied by a reduction in Th1 cells in the spleen, consistent with the observed reduction in specific IgG concentration. The precise mechanisms by which 90Sr acts on the immune system remain to be elucidated. However, our results suggest that 90Sr ingestion may be responsible for some of the reported effects of internal contamination on the immune system in civilian populations exposed to the Chernobyl fallout. © 2016 by Radiation Research Society. |
| Databáze: | OpenAIRE |
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