A longitudinal study of computerized cognitive training in stroke patients - effects on cognitive function and white matter

Autor: Anders M. Fjell, Donatas Sederevicius, Frank Becker, Jan Egil Nordvik, Claudia Kim Nyberg, Darius A. Rohani, Kristine B. Walhovd
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Longitudinal study
Adolescent
Neuropsychological Tests
050105 experimental psychology
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
Physical medicine and rehabilitation
medicine
Image Processing
Computer-Assisted

Humans
0501 psychology and cognitive sciences
Cognitive rehabilitation therapy
Longitudinal Studies
Stroke
Aged
Community and Home Care
Analysis of Variance
Cognitive Behavioral Therapy
business.industry
Working memory
05 social sciences
Rehabilitation
Stroke Rehabilitation
Cognition
Middle Aged
medicine.disease
White Matter
Cognitive training
medicine.anatomical_structure
Diffusion Tensor Imaging
Memory
Short-Term

Anisotropy
Female
Neurology (clinical)
business
Cognition Disorders
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Topics in stroke rehabilitation. 25(4)
ISSN: 1945-5119
1074-9357
Popis: Background Computerized cognitive training is suggested to enhance attention and working memory functioning following stroke, but effects on brain and behavior are not sufficiently studied and longitudinal studies assessing brain and behavior relationships are scarce. Objective The study objectives were to investigate relations between neuropsychological performance post-stroke and white matter microstructure measures derived from diffusion tensor imaging (DTI), including changes after 6 weeks of working memory training. Methods In this experimental training study, 26 stroke patients underwent DTI and neuropsychological tests at 3 time points – before and after a passive phase of 6 weeks, and again after 6 weeks of working memory training (Cogmed QM). Fractional anisotropy (FA) was extracted from stroke-free brain areas to assess the white matter microstructure. Twenty-two participants completed the majority of training (≥18/25 sessions) and were entered into longitudinal analyses. Results Significant correlations between FA and baseline cognitive functions were observed (r = 0.58, p = 0.004), however, no evidence was found of generally improved cognitive functions following training or of changes in white matter microstructure. Conclusions While white matter microstructure related to baseline cognitive function in stroke patients, the study revealed no effect on cognitive functions or microstructural changes in white matter in relation to computerized working memory training.
Databáze: OpenAIRE