A longitudinal study of computerized cognitive training in stroke patients - effects on cognitive function and white matter
Autor: | Anders M. Fjell, Donatas Sederevicius, Frank Becker, Jan Egil Nordvik, Claudia Kim Nyberg, Darius A. Rohani, Kristine B. Walhovd |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male medicine.medical_specialty Longitudinal study Adolescent Neuropsychological Tests 050105 experimental psychology White matter 03 medical and health sciences Young Adult 0302 clinical medicine Physical medicine and rehabilitation medicine Image Processing Computer-Assisted Humans 0501 psychology and cognitive sciences Cognitive rehabilitation therapy Longitudinal Studies Stroke Aged Community and Home Care Analysis of Variance Cognitive Behavioral Therapy business.industry Working memory 05 social sciences Rehabilitation Stroke Rehabilitation Cognition Middle Aged medicine.disease White Matter Cognitive training medicine.anatomical_structure Diffusion Tensor Imaging Memory Short-Term Anisotropy Female Neurology (clinical) business Cognition Disorders 030217 neurology & neurosurgery Diffusion MRI |
Zdroj: | Topics in stroke rehabilitation. 25(4) |
ISSN: | 1945-5119 1074-9357 |
Popis: | Background Computerized cognitive training is suggested to enhance attention and working memory functioning following stroke, but effects on brain and behavior are not sufficiently studied and longitudinal studies assessing brain and behavior relationships are scarce. Objective The study objectives were to investigate relations between neuropsychological performance post-stroke and white matter microstructure measures derived from diffusion tensor imaging (DTI), including changes after 6 weeks of working memory training. Methods In this experimental training study, 26 stroke patients underwent DTI and neuropsychological tests at 3 time points – before and after a passive phase of 6 weeks, and again after 6 weeks of working memory training (Cogmed QM). Fractional anisotropy (FA) was extracted from stroke-free brain areas to assess the white matter microstructure. Twenty-two participants completed the majority of training (≥18/25 sessions) and were entered into longitudinal analyses. Results Significant correlations between FA and baseline cognitive functions were observed (r = 0.58, p = 0.004), however, no evidence was found of generally improved cognitive functions following training or of changes in white matter microstructure. Conclusions While white matter microstructure related to baseline cognitive function in stroke patients, the study revealed no effect on cognitive functions or microstructural changes in white matter in relation to computerized working memory training. |
Databáze: | OpenAIRE |
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