A prospective study of acute idiopathic neuropathy. II. Antecedent events
| Autor: | M J Anderson, J B Winer, H. O. Kangro, R P Watkins, D M Jones, Richard A. C. Hughes |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Polyradiculoneuropathy Congenital cytomegalovirus infection Antibodies Viral medicine.disease_cause Campylobacter jejuni Autoimmune Diseases Idiopathic Neuropathy Risk Factors Internal medicine medicine Humans Child Prospective cohort study Respiratory Tract Infections Aged biology Parvovirus business.industry Incidence (epidemiology) Bacterial Infections Mycoplasma Middle Aged biology.organism_classification medicine.disease Antibodies Bacterial Epstein–Barr virus Gastroenteritis Psychiatry and Mental health Virus Diseases Child Preschool Immunology Female Surgery Neurology (clinical) business Research Article |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 51:613-618 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.51.5.613 |
| Popis: | The incidence of antecedent events and serological evidence of preceding infection were studied in 100 patients with acute idiopathic neuropathy and age and sex matched control subjects in South-East England. Symptoms of respiratory infections occurred within one month before onset of neuropathic symptoms in 38% of patients and 12% of controls (p less than 0.001) and symptoms of gastrointestinal infections in 17% of patients and 3% of controls (p less than 0.005). Immunisations, insect bites and animal contact were equally common in the patient and control subjects. Eight per cent of patients had undergone an operation within the preceding 3 months. Six per cent of patients had co-existing "autoimmune" diseases. Serological evidence of recent infection was identified in 31% of patients. Campylobacter jejuni (14%) and cytomegalovirus (11%) were both significantly more frequently demonstrated in patients than controls. Serological evidence of recent infection with mycoplasma (1%), Epstein Barr virus (1-2%) and parvovirus B19 (4%) was also identified in the patients but not more frequently than in the controls. Possible explanations for the association of these agents with acute idiopathic neuropathy include possession of antigens shared with myelin and inhibition of suppressor mechanisms. |
| Databáze: | OpenAIRE |
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