Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial

Autor: Dominique Januel, Marie-Laure Grillon, Corinne Launay, Hélène Verdoux, Marie-Cécile Bralet, Pascal Bloch, Isabelle Amado, Til Wykes, Benjamin Riche, F. Petitjean, Chloé Duboc, Vincent Le Roy, Patricia Deppen, Charlotte Sundby, Sandrine Foullu, Pascal Vianin, Patrick Briant, Pascal Roy, Caroline Demily, Aurélia Todd, Dominique Willard, Nicolas Franck
Přispěvatelé: Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Service de Biostatistiques [Lyon], Hospices Civils de Lyon (HCL)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Schizophrenia Research
Schizophrenia Research, 2013, 147, pp.68--74. ⟨10.1016/j.schres.2013.03.009⟩
Schizophrenia Research, Elsevier, 2013, 147, pp.68--74. ⟨10.1016/j.schres.2013.03.009⟩
ISSN: 0920-9964
DOI: 10.1016/j.schres.2013.03.009⟩
Popis: Background This study assesses the benefits of an individualized therapy (RECOS program) compared with the more general cognitive remediation therapy (CRT). Methods 138 participants took part with 65 randomized to CRT and 73 to RECOS. In the RECOS group, participants were directed towards one of five training modules (verbal memory, visuo-spatial memory and attention, working memory, selective attention or reasoning) corresponding to their key cognitive concern whereas the CRT group received a standard program. The main outcome was the total score on BADS (Behavioural Assessment of Dysexecutive Syndrome) and the secondary outcomes were: cognition (executive functions; selective attention; visuospatial memory and attention; verbal memory; working memory) and clinical measures (symptoms; insight; neurocognitive complaints; self-esteem). All outcomes were assessed at baseline (T1), week 12 (posttherapy, T2), and follow-up (week 36, i.e., 6 months posttherapy, T3). Results No difference was shown for the main outcome. A significant improvement was found for BADS' profile score for RECOS at T2 and T3, and for CRT at T3. Change in BADS in the RECOS and CRT arms were not significantly different between T1 and T2 (+ 0.86, p = 0.108), or between T1 and T3 (+ 0.36, p = 0.540). Significant improvements were found in several secondary outcomes including cognition (executive functions, selective attention, verbal memory, and visuospatial abilities) and clinician measures (symptoms and awareness to be hampered by cognitive deficits in everyday) in both treatment arms following treatment. Self-esteem improved only in RECOS arm at T3, and working memory improved only in CRT arm at T2 and T3, but there were no differences in changes between arms. Conclusions RECOS (specific remediation) and CRT (general remediation) globally showed similar efficacy in the present trial.
Databáze: OpenAIRE
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