Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometry
| Autor: | Jens-Peter Weller, Thomas Rothämel, Jörg Teske, A. Fieguth, Hans Dieter Tröger, Yvonne Schulz |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
Quality Control Spectrometry Mass Electrospray Ionization Cannabinoid receptor Indoles medicine.drug_class Clinical Biochemistry Marijuana Smoking Naphthalenes Biochemistry Analytical Chemistry Ingredient Liquid chromatography–mass spectrometry Limit of Detection Tandem Mass Spectrometry medicine Humans Chromatography High Pressure Liquid Active ingredient Detection limit Cannabinoid Receptor Agonists Chromatography Chemistry Cell Biology General Medicine Serum concentration JWH-018 Reference Standards Calibration medicine.drug |
| Zdroj: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 878(27) |
| ISSN: | 1873-376X |
| Popis: | The current paper describes a validated method for the detection and quantification of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018), an ingredient of a herbal mixture called "Spice", by means of HPLC-ESI-MS-MS in serum. Lower limit of detection and lower limit of quantification were 0.07 and 0.21 ng/ml, respectively. In 2 subjects who consumed ca. 50 μg/kg of JWH-018 by smoking, the active ingredient was detected by means of the described method. Thereby, the serum concentrations reached values of approx. 10 ng/ml and dropped within 3 h very fast ( |
| Databáze: | OpenAIRE |
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