Efficacy of blood flow restriction exercise during dialysis for end stage kidney disease patients: protocol of a randomised controlled trial

Autor: Catherine Brumby, Matthew J. Clarkson, Paul Bennett, Lawrence P. McMahon, Steven F. Fraser, Stuart A. Warmington
Přispěvatelé: Clarkson, Matthew J, Fraser, Steve F, Bennett, Paul N, McMahon, Lawrence P, Brumby, Catherine, Warmington, Stuart A
Rok vydání: 2017
Předmět:
Male
medicine.medical_treatment
Physical fitness
030232 urology & nephrology
lcsh:RC870-923
law.invention
Study Protocol
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Young adult
Aged
80 and over
exercise
End-stage kidney disease
Middle Aged
Exercise Therapy
Nephrology
Physical function
Female
Strength
strength
Blood Flow Velocity
Adult
Blood flow restriction exercise
medicine.medical_specialty
Adolescent
blood flow restriction exercise
end-stage kidney disease
03 medical and health sciences
Young Adult
physical function
Rating scale
Renal Dialysis
medicine
Aerobic exercise
Humans
Exercise
Dialysis
Aged
business.industry
030229 sport sciences
lcsh:Diseases of the genitourinary system. Urology
Clinical trial
Physical Fitness
Regional Blood Flow
Physical therapy
dialysis
Kidney Failure
Chronic
business
Zdroj: BMC Nephrology
BMC Nephrology, Vol 18, Iss 1, Pp 1-9 (2017)
ISSN: 1471-2369
Popis: Background Exercise during haemodialysis improves strength and physical function. However, both patients and clinicians are time poor, and current exercise recommendations add an excessive time burden making exercise a rare addition to standard care. Hypothetically, blood flow restriction exercise performed during haemodialysis can provide greater value for time spent exercising, reducing this time burden while producing similar or greater outcomes. This study will explore the efficacy of blood flow restriction exercise for enhancing strength and physical function among haemodialysis patients. Methods This is a randomised controlled trial design. A total of 75 participants will be recruited from haemodialysis clinics. Participants will be allocated to a blood flow restriction cycling group, traditional cycling group or usual care control group. Both exercising groups will complete 3 months of cycling exercise, performed intradialytically, three times per week. The blood flow restriction cycling group will complete two 10-min cycling bouts separated by a 20-min rest at a subjective effort of 15 on a 6 to 20 rating scale. This will be done with pressurised cuffs fitted proximally on the active limbs during exercise at 50% of a pre-determined limb occlusion pressure. The traditional cycling group will perform a continuous 20-min bout of exercise at a subjective effort of 12 on the same subjective effort scale. These workloads and volumes are equivalent and allow for comparison of a common blood flow restriction aerobic exercise prescription and a traditional aerobic exercise prescription. The primary outcome measures are lower limb strength, assessed by a three repetition maximum leg extension test, as well as objective measures of physical function: six-minute walk test, 30-s sit to stand, and timed up and go. Secondary outcome measures include thigh muscle cross sectional area, body composition, routine pathology, quality of life, and physical activity engagement. Discussion This study will determine the efficacy of blood flow restriction exercise among dialysis patients for improving key physiological outcomes that impact independence and quality of life, with reduced burden on patients. This may have broader implications for other clinical populations with similarly declining muscle health and physical function, and those contraindicated to higher intensities of exercise. Trial registration Australian and New Zealand Clinical Trial Register: ACTRN12616000121460.
Databáze: OpenAIRE
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