Pharmacokinetics and metabolic rates of acetyl salicylic acid and its metabolites in an Otomi ethnic group of Mexico
Autor: | Adrián Guillé-Pérez, Arturo Vargas, Hugo Juárez-Olguín, Ismael Lares-Asseff, Janett Flores-Pérez |
---|---|
Rok vydání: | 2004 |
Předmět: |
Adult
Male Adolescent Metabolic Clearance Rate Pharmaceutical Science Urine Pharmacology Statistics Nonparametric Hydrolysis chemistry.chemical_compound Pharmacokinetics medicine Humans Gentisic acid Mexico Aspirin Chemistry General Medicine Metabolism Salicyluric acid Indians North American Female Salicylic acid medicine.drug |
Zdroj: | Biologicalpharmaceutical bulletin. 27(5) |
ISSN: | 0918-6158 |
Popis: | The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included. After a single dose of aspirin given orally (15 mg/kg), blood and urine samples were collected at different times. Results. Pharmacokinetic parameters of salicylates showed significant differences, except distribution volume of SA, and elimination half-life of SUA. Metabolic rates of ASA showed significant differences for all rates between both groups. On the other hand, percentages of dose excreted were more reduced for SA and SUA for the Otomies than for the Mesticians. Conclusion. Results reflect differences in the hydrolysis way i.e. from ASA to SA and aromatic hydroxylation i.e. from SA to GA, which were slower in Otomies subjects, showing a possible pharmacokinetic differences about the capabilities of ASA biotransformation as a consequence of ethnic differences. |
Databáze: | OpenAIRE |
Externí odkaz: |