What makes oncogenes mutually exclusive?
| Autor: | Jaroslaw Cisowski, Martin O. Bergo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Senescence Biology medicine.disease_cause Mutually exclusive events Biochemistry DNA sequencing 03 medical and health sciences Neoplasms medicine Animals Humans Gene Cellular Senescence Genetics Mutation Cell Death Oncogene Cancer Oncogenes Cell Biology medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Commentary Signal transduction |
| Zdroj: | Small GTPases. 8:187-192 |
| ISSN: | 2154-1256 2154-1248 |
| DOI: | 10.1080/21541248.2016.1212689 |
| Popis: | Cancer is driven by mutations in genes whose products participate in major signaling pathways that fuel cell proliferation and survival. It is easy to assume that the more of these so-called driver mutations a tumor accumulates, the faster it progresses. However, this does not appear to be the case: Data from large-scale genome sequencing studies indicate that mutations in driver oncogenes often are mutually exclusive. The mechanisms underlying the mutual exclusivity of oncogenes are not completely understood, but recent reports suggest that the mechanisms may depend on the tumor type, and the nature of interacting oncogenes. Here we discuss our recent findings that the oncogenes KRASG12D and BRAFV600E are mutually exclusive in lung cancer in mouse models because their coexpression leads to oncogene-induced senescence. |
| Databáze: | OpenAIRE |
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