Meta-analysis of prognostic value of inflammation parameter in breast cancer
| Autor: | Shukui Wang, Xian Liu, Qiwen Deng, Bangshun He, Houqun Ying, Jie Chen, Huiling Sun, Yuqin Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Multivariate analysis inflammation parameter Breast Neoplasms Context (language use) lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Tumor Microenvironment medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Metastasis Neutrophil to lymphocyte ratio Neoplasm Staging Inflammation business.industry Hazard ratio fungi General Medicine medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis Confidence interval 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Female prognosis business |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 14, Iss 8, Pp 85-89 (2018) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Context: Recently, increasing studies investigated the association between inflammation parameter such as neutrophil to lymphocyte ratio (NLR) and the prognosis of cancers. However, the clinical and prognostic significance of NLR in breast cancer remains controversial. Aim: This meta-analysis was conducted to establish the overall accuracy of the NLR test in the diagnosis of breast cancer. Materials and Methods: A comprehensive search of the literature was conducted using PubMed and Web of Science. Six studies dating up to July 2014 with 2267 patients were enrolled in the present study. STATA 11.0 software (STATA Corporation, College Station, TX, USA) was selected for data analysis. In order to evaluate the association between NLR and overall survival (OS), disease-free survival (DFS), recurrence-free survival or cancer-specific survival, the hazard ratios (HRs), and their 95% confidence intervals (CIs) were extracted. Results: Subgroup analyses showed that NLR was a strong prognostic factor for OS in multivariate analysis (HR = 2.81, 95% CI = 2.13–3.71, PH = 0.992) and without metastasis (HR = 1.45, 95% CI = 0.37–5.66, PH < 0.001). Elevated NLR was associated with a high risk for DFS in subgroups of multivariate analysis (HR = 2.16, 95% CI = 1.67–2.80, PH = 0.977) and mixed metastasis (HR = 2.13, 95% CI = 1.38–3.30, PH = 0.84). Conclusion: In summary, NLR may be considered as a predictive factor for patients with breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|