Evaluation Of Histone Deacetylase Inhibitor Substituted Zinc And Indium Phthalocyanines For Chemo- And Photodynamic Therapy
| Autor: | Basak Aru, Aysel Günay, Gulderen Yanikkaya Demirel, Ayşe Gül Gürek, Devrim Atilla |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
General Chemical Engineering medicine.medical_treatment Histone deacetylase inhibitor chemistry.chemical_element Photodynamic therapy General Chemistry Zinc In vitro Endothelial stem cell chemistry.chemical_compound chemistry medicine Phthalocyanine Biophysics Photosensitizer Cellular localization |
| Popis: | In this study, we synthesized and characterized 3-hydroxypyridin-2-thione (3-HPT) bearing zinc (ZnPc-1 and ZnPc-2) and indium (InPc-1 and InPc-2) phthalocyanine (Pc) derivatives, either non-peripherally or peripherally substituted as photosensitizer (PS) agents and evaluated their anti-cancer efficacy on two breast cancer cell lines, MDA-MB-231 and MCF-7 as well as a human endothelial cell line, HUVEC. Our results indicated different localization patterns between ZnPcs and InPcs in addition to enhanced effects on the mitochondrial network for InPcs. Moreover, peripheral or non-peripheral substitution of HDACi moieties altered cellular localization between ZnPc-1 and ZnPc-2, leading to increased IC50 values along with decreased anti-cancer activity for non-peripheral substitution. When considering the compounds' differential effects in vitro, our data indicates that further research is required to determine the ideal Pcs for anti-cancer PDT treatments since the core metals of the compounds have affected the cellular localization, and positioning of the chemotherapeutic residues may inhibit cellular penetrance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|