Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

Autor: Céline Bazille, Catherine Baugé, Eva Lhuissier, Nicolas Girard, Karim Boumediene
Přispěvatelé: Microenvironnement et Pathologies du Cartilage (BioConnecT), Microenvironnement cellulaire et pathologie (MILPAT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU), Laboratoire d'Anatomie Pathologique [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN)
Rok vydání: 2014
Předmět:
MESH: Signal Transduction
[SDV]Life Sciences [q-bio]
chondrocytes
Review Article
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Bioinformatics
Chondrocyte
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
MESH: Osteoarthritis
MESH: Chondrocytes
chondrogenesis
TGF beta signaling pathway
medicine
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
cartilage
Receptor
MESH: Transforming Growth Factor beta
030304 developmental biology
0303 health sciences
MESH: Hypertrophy
Cartilage
aging
Cell Biology
Transforming growth factor beta
Chondrogenesis
Hedgehog signaling pathway
Cell biology
osteoarthritis
medicine.anatomical_structure
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
MESH: Cartilage
030220 oncology & carcinogenesis
biology.protein
Neurology (clinical)
Geriatrics and Gerontology
Signal transduction
signal transduction
MESH: Chondrogenesis
Zdroj: Aging and disease
Aging and disease, Kunlin Jin, 2014, 5 (6), pp.394-405. ⟨10.14336/AD.2014.0500394⟩
ISSN: 2152-5250
DOI: 10.14336/ad.2014.0500394
Popis: International audience; Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.
Databáze: OpenAIRE
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