Safety of intravitreal triamcinolone and its impact on optic nerve morphology in patients treated for diabetic macular edema
| Autor: | Paula Telles Freitas, Nuno Campos, Ana Rita Carreira, Joao Cardoso, nadine sousa marques, Filipe Moraes, Pedro Carreira, Tomás Loureiro |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
030213 general clinical medicine
medicine.medical_specialty Intraocular pressure Triamcinolone acetonide genetic structures Nerve fiber layer Ocular hypertension Glaucoma Triamcinolone Acetonide Macular Edema 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Diabetes Mellitus medicine Humans Glucocorticoids Intraocular Pressure Aged Retrospective Studies Diabetic Retinopathy business.industry Optic Nerve Retinal General Medicine Middle Aged medicine.disease eye diseases Topical medication Treatment Outcome medicine.anatomical_structure chemistry Intravitreal Injections 030221 ophthalmology & optometry Optic nerve Ocular Hypertension business medicine.drug |
| Zdroj: | European Journal of Ophthalmology. 32:1596-1601 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/11206721211028744 |
| Popis: | Purpose: To assess the impact of one intravitreal injection (IVT) of Triamcinolone Acetonide (TA) on intraocular pressure (IOP) and optic nerve structural parameters in patients treated for Diabetic Macular Edema (DME). Methods: This retrospective study included patients with DME that were naïve to intraocular steroids and underwent one IVT of TA of 4 mg/0.1 mL and age-matched controls with DME without criteria for IVT. Patients records were reviewed for IOP (at baseline and a month after IVT) and optic nerve parameters measured by optical coherence tomography (up to 6 months before and 6 months after IVT). Exclusion criteria included glaucoma and treatment with hypotensive agents. Results: Twenty-six eyes were included in the Control Group and 29 in the IVT Group, with a mean age of 65.10 ± 10.08 and 67.30 ± 4.71 years, respectively ( p = 0.06). At baseline, IOP and optic nerve measurements were equivalent between groups ( p > 0.05). One month after IVT, mean IOP measurements in IVT Group were higher than those of controls (17.84 ± 4.50 vs 11.59 ± 3.09 mmHg, p < 0.001). Ocular hypertension (OHT) developed in 17.24% of cases and reversed with topical medication. After one IVT, vertical cup/disc ratio was higher (0.57 ± 0.25 vs 0.60 ± 0.14, p = 0.04) and retinal nerve fiber layer thickness was globally lower (mean: 91.03 ± 4.25 vs 81.33 ± 19.10 µm, p = 0.001) in the IVT Group. Conclusion: Our results confirmed that intravitreal TA results in IOP increase. This seems to negatively affect optic nerve morphology, even in patients without OHT or adequately treated with hypotensive agents. |
| Databáze: | OpenAIRE |
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