Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood
| Autor: | Camden P. Bay, Jill M. Goldstein, Shalender Bhasin, Eric B. Loucks, Bill L. Lasley, Steve Buka, Robert J. Handa, Stephen E. Gilman, Akhgar Ghassabian, Sarah A. Aroner, Grace Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Offspring medicine.drug_class Pregnancy Trimester Third Endocrinology Diabetes and Metabolism Birth weight Physiology Weight Gain Article Body Mass Index Cohort Studies Child Development Sex Factors Endocrinology New England Pregnancy medicine Birth Weight Humans Early childhood Child Correlation of Data business.industry Infant Newborn Prenatal Care Androgen medicine.disease Low birth weight Child Preschool Androgens Body-Weight Trajectory Female medicine.symptom business Weight gain Body mass index |
| Zdroj: | J Endocrinol Invest |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-020-01385-4 |
| Popis: | CONTEXT: In preclinical studies, high androgen levels during pregnancy are associated with low birth weight and rapid postnatal weight gain in the offspring. However, human data linking prenatal androgens with birth weight and early life weight gain in the offspring are scarce. DESIGN: We evaluated 516 mother-child pairs enrolled in the New England birth cohorts of the Collaborative Perinatal Project (1959-1966). We assayed androgen bioactivity in maternal sera during third-trimester using a receptor-mediated luciferase expression bioassay. Age and sex-specific BMI Z-scores (BMIz), defined using established standards, were assessed at birth, 4-months, 1-year, 4-years and 7-years. We used linear mixed models to evaluate the relation of maternal androgens with childhood BMIz overall and by sex. We examined the association of maternal androgens with fetal growth restriction. The association of weight trajectories with maternal androgens was examined using multinomial logistic regression. RESULTS: Higher maternal androgen levels associated with lower BMIz at birth (β=−0.39, 95%CI: −0.73, −0.06);this relation was sex-dependent such that maternal androgens significantly associated with BMIz at birth in girls alone (β=−0.72, 95%CI: −1.40, −0.04). The relation of maternal androgens with fetal growth restriction revealed dose threshold effects that differed by sex. There was no significant association between maternal androgens and weight trajectory overall. However, we found a significant sex interaction (p=0.01); higher maternal androgen levels associated with accelerated catch-up growth in boys (aOR=2.14, 95%CI: 1.14, 4.03). CONCLUSION: Our findings provide evidence that maternal androgens may have differential effects on programming of intrauterine growth and postnatal weight gain depending on fetal sex. |
| Databáze: | OpenAIRE |
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