Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials
| Autor: | Christine J. Harrison, Elli Papaemmanuil, Ellie Butler, Emilio Barretta, Anthony V. Moorman, Daniel Leongamornlert, Andrew McMillan, Nick Morley, Thomas Creasey, Laura Clifton-Hadley, Tobias Menne, Amy A Kirkwood, Clare J. Rowntree, Bela Patel, Adele K. Fielding, Sarra Ryan, David I. Marks, Pip Patrick |
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| Rok vydání: | 2021 |
| Předmět: |
Gene Rearrangement
Oncology medicine.medical_specialty business.industry Incidence (epidemiology) Single-nucleotide polymorphism Genomics Hematology Disease Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Cohort Studies Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Internal medicine Cohort medicine Humans Hypodiploidy SNP Hyperdiploidy Child business Aged SNP array |
| Zdroj: | Haematologica. 107:2051-2063 |
| ISSN: | 1592-8721 0390-6078 |
| Popis: | Despite being predominantly a childhood disease, the incidence of acute lymphoblastic leukemia (ALL) has a second peak in adults aged 60 years and over. These older adults fare extremely poorly with existing treatment strategies and very few studies have undertaken a comprehensive genetic and genomic characterization to improve prognosis in this age group. We performed cytogenetic, single nucleotide polymorphism (SNP) array and next-generation sequencing (NGS) analyses on samples from 210 patients aged ≥60 years from the UKALL14 and UKALL60+ clinical trials. BCR-ABL1-positive disease was present in 26% (55/210) of patients, followed by low hypodiploidy/near triploidy in 13% (28/210). Cytogenetically cryptic rearrangements in CRLF2, ZNF384 and MEF2D were detected in 5%, 1% and |
| Databáze: | OpenAIRE |
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