Hypochlorous acid facilitates inducible nitric oxide synthase subunit dissociation: The link between heme destruction, disturbance of the zinc-tetrathiolate center, and the prevention by melatonin

Autor:	Olivia G, Camp, David, Bai, Awoniyi, Awonuga, Pravin T, Goud, Husam M, Abu-Soud
Rok vydání:	2022
Předmět:	Cancer Research Physiology Clinical Biochemistry Nitric Oxide Synthase Type II Heme Hydrogen Peroxide Arginine Nitric Oxide Biochemistry Hypochlorous Acid Zinc Oxygenases Humans Nitric Oxide Synthase Oxidoreductases Melatonin
Zdroj:	Nitric Oxide. 124:32-38
ISSN:	1089-8603
DOI:	10.1016/j.niox.2022.04.006
Popis:	Inducible nitric oxide synthase (iNOS) is a zinc-containing hemoprotein composed of two identical subunits, each containing a reductase and an oxygenase domain. The reductase domain contains binding sites for NADPH, FAD, FMN, and tightly bound calmodulin and the oxygenase domain contains binding sites for heme, tetrahydrobiopterin (H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7cf8f3d3d4f66d6be3978be4bb56f5 https://doi.org/10.1016/j.niox.2022.04.006 Zobrazit plný text záznamu Full Text from ScienceDirect