Cooperative control of translational fidelity by ribosomal proteins in Escherichia coli
| Autor: | R. Villarroel, Albert Herzog, Andrew W. Bollen, M. De Wilde, T Cabezon |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Ribosomal Proteins
Genetics Mutant Structural gene Drug Resistance Microbial Biology Ribosomal RNA medicine.disease_cause Ribosome Phenotype Bacterial Proteins Genes Ribosomal protein Protein Biosynthesis Mutation Mutation (genetic algorithm) Escherichia coli Streptomycin medicine Molecular Biology Gene |
| Zdroj: | Molecular and General Genetics MGG. 144:59-62 |
| ISSN: | 1432-1874 0026-8925 |
| DOI: | 10.1007/bf00277305 |
| Popis: | The effect on translational fidelity of a particular mutation in the gene coding for protein S5(rpxE) has been investigated. This mutation has the opposite effect of a restrictive strA mutation; in vivo, it relieves the restriction imposed by strA on the suppression of T4 nonsense mutants and results in hypersensitivity to streptomycin; in vitro, the presence of the altered S5 protein in 30S ribosomes results in increased intrinsic misreading. It is concluded that this mutation, ramC319, acts as a ribosomal ambiguity mutation similar to certain mutations of protein S4 (ramA). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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