Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins
| Autor: | Alexander Prosekov, Stanislav Sukhikh, Margarita A. Shevchenko, Maria Zimina, Olga Babich, Svetlana Ivanova, Svetlana Noskova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Review Computational biology cytotoxic action Biochemistry Microbiology activity of bacteriocins bacteriocins PCR reactions 03 medical and health sciences Bacteriocin Effective treatment Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Secondary metabolism Pcr analysis 030304 developmental biology 0303 health sciences biology 030306 microbiology lcsh:RM1-950 food and beverages biochemical phenomena metabolism and nutrition biology.organism_classification Cancer treatment Infectious Diseases antimicrobial action lcsh:Therapeutics. Pharmacology probiotics Antimicrobial action Classification methods bacteria Bacteria |
| Zdroj: | Antibiotics, Vol 9, Iss 553, p 553 (2020) Antibiotics |
| ISSN: | 2079-6382 |
| Popis: | This paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. It is established that the main method of bacteriocin research is PCR analysis, which makes it possible to quickly and easily identify the presence of bacteriocin encoding genes. The mechanism of cytotoxic action of bacteriocins has been studied. It is proved that the study of cytotoxic (antitumor) activity in laboratory conditions will lead to the clinical use of bacteriocins for cancer treatment in the near future. It is established that the incorporation of bacteriocins into nanoparticles and targeted delivery to areas of infection may soon become an effective treatment method. The delivery of bacteriocins in a concentrated form, such as encapsulated in nanoparticles, will increase their effectiveness and minimize potential toxic side effects. The analysis of publications on this topic confirmed that diverse research on bacteriocins is relevant. |
| Databáze: | OpenAIRE |
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