Parotid and whole saliva in the prediction of serum total and free phenytoin concentrations
| Autor: | Clarence E. Cook, William M. Wardell, Fred G. Emmings, Ira Shoulson, Anthony J. Gringeri, Sadanand N. Anavekar, Ralph H. Saunders |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male Phenytoin Drug medicine.medical_specialty Saliva media_common.quotation_subject Radioimmunoassay Ultrafiltration Gingivitis Internal medicine Methods otorhinolaryngologic diseases Humans Parotid Gland Medicine heterocyclic compounds Pharmacology (medical) Whole saliva Aged media_common Pharmacology business.industry digestive oral and skin physiology Middle Aged nervous system diseases stomatognathic diseases Endocrinology Linear relationship Female Parotid saliva Free phenytoin medicine.symptom business medicine.drug |
| Zdroj: | Clinical Pharmacology & Therapeutics. 24:629-637 |
| ISSN: | 0009-9236 |
| DOI: | 10.1002/cpt1978246629 |
| Popis: | Epileptic outpatients (22 male and 12 female) participated in this study. All were taking phenytoin and 20 were taking one or more additional antiepileptic drugs. The mean percent free phenytoin in serum was 11.0% whether the patient was taking phenytoin alone or in combination with other antiepileptic drugs. There was a strong linear relationship between the serum total and ultrafiltrate phenytoin concentrations, the slope of the regression line being 0.109. There was also a strong relationship between the phenytoin concentrations in serum ultra filtrate and each of four salivary fractions, but each salivary fraction significantly underestimated the mean serum ultrafiltrate phenytoin concentration. It should be noted, however, that in this study the saliva fractions collected were relatively large (7 ml), and it is possible that collection conditions such as these may influence the salivary phenytoin concentration. The supernatant of whole saliva had a significantly lower concentration of phenytoin than whole saliva itself (due to binding of the drug to the mucoid sediment). Parotid saliva appears to be the best predictor of serum ultrafiltrate phenytoin concentrations. Contrary to expectation, gingivitis, at least as defined here, appeared to have no effect on the predictability of serum ultrafiltrate phenytoin concentrations by the salivary fractions, but this conclusion is a qualified one. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|