Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals

Autor: Brian Giunta, Lukasz Wojtas, Naga Kiran Duggirala, R. Douglas Shytle, Jared Ehrhart, Michael J. Zaworotko, Seol-Hee Kim, Adam J. Smith, Jingji Jin, Jun Tan
Rok vydání: 2013
Předmět:
Zdroj: Molecular Pharmaceutics
ISSN: 1543-8392
1543-8384
Popis: Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a narrow therapeutic window. Recent attempts to find alternative drugs have identified new chemical entities, but lithium's polypharmacological mechanisms for treating neuropsychiatric disorders are highly debated and are not yet matched. Thus, re-engineering current lithium solid forms in order to optimize performance represents a low cost and low risk approach to the desired therapeutic outcome. In this contribution, we employed a crystal engineering strategy to synthesize the first ionic cocrystals (ICCs) of lithium salts with organic anions. We are unaware of any previous studies that have assessed the biological efficacy of any ICCs, and encouragingly we found that the new speciation did not negatively affect established bioactivities of lithium. We also observed that lithium ICCs exhibit modulated pharmacokinetics compared to lithium carbonate. Indeed, the studies detailed herein represent an important advancement in a crystal engineering approach to a new generation of lithium therapeutics.
Databáze: OpenAIRE