trans-2,6-, 3,6- and 4,6-Diaza-5,6,6a,7,8,12b-hexahydrobenzo[C]phenanthrene-10,11-diols as dopamine agonists
| Autor: | Yu Gui Gu, Erol K. Bayburt, Michael R. Michaelides, Chun Wei Lin, Kazumi Shiosaki |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Receptors
Dopamine D2 Chemistry Stereochemistry Receptors Dopamine D1 Attention deficit disorder Organic Chemistry Clinical Biochemistry Pharmaceutical Science Phenanthrene Ring (chemistry) Biochemistry Chemical synthesis Phenanthridines Structure-Activity Relationship chemistry.chemical_compound Dopamine Dopamine Agonists Drug Discovery Pyridine medicine Humans Molecular Medicine Cognitive impairment Molecular Biology medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:1341-1346 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00214-0 |
| Popis: | A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached comprise a pyridine ring selected from: ##STR2## wherein R 1 , R 2 , and R 3 are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder, and methods for the preparation thereof. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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