Early steroid withdrawal in pediatric renal transplant on newer immunosuppressive drugs
| Autor: | E. Buckel, Jorge Rodríguez, Jorge Godoy, Francisco Cano, Eugenio E Rodriguez, Gabriel Cavada, Angela Delucchi, Luis Contreras, Mario Ferrario, J. Luis Guerrero, Ana Maria Lillo, Marcela Valenzuela, C. Gloria Gonzalez |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Time Factors Adolescent medicine.drug_class Basiliximab Recombinant Fusion Proteins medicine.medical_treatment Urinary system Renal function Gastroenterology Drug Administration Schedule Steroid Adrenal Cortex Hormones Internal medicine medicine Humans Prospective Studies Child Kidney transplantation Transplantation Kidney business.industry Puberty Antibodies Monoclonal Immunosuppression medicine.disease Kidney Transplantation Treatment Outcome medicine.anatomical_structure Endocrinology Child Preschool Pediatrics Perinatology and Child Health Corticosteroid business Immunosuppressive Agents medicine.drug |
| Zdroj: | Pediatric Transplantation. 11:743-748 |
| ISSN: | 1399-3046 1397-3142 |
| Popis: | Steroids have been a cornerstone in renal transplant immunosuppression. New immunosuppressive drugs have led to protocols using early steroid withdrawal or complete avoidance. A prospective protocol in 23 pediatric renal transplant (ages 2-14 yr) who received decreasing steroid doses stopping at day 7 post-Tx, FK, and MMF were compared with a CsA, AZT, historically matched steroid-based control group. Basiliximab was used in two doses. Anthropometric, biochemical variables, AR rates, and CMV infection were evaluated and compared using Student's t-test and regression analysis. A better growth pattern was seen in steroid withdrawal group. GFR rate and serum glucose were similar in both groups. Total serum cholesterol levels were significantly lower in steroid withdrawal group. The incidence of AR at 12 months was 4.3% in steroid withdrawal group vs. 8.6% in steroid-based group (p = ns). No difference in CMV infection was observed. Hemoglobin levels were low during the first months in both groups; reached normal values after six months. SBP became higher at 12 months in steroid-based group. Patient and graft survival was 98% in both groups at one-yr post-transplant. Early steroid withdrawal was efficacious, safe, and did not increase risk of rejection, preserving optimal growth, renal function, and reducing cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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