Rhodococcus fascians infection after haematopoietic cell transplantation: not just a plant pathogen?
Autor: | Susan M. Butler-Wu, Teal S. Hallstrand, Karen Stephens, Melissa C. Austin, Cecilia C. S. Yeung, Gregory Balmforth, Daniel R. Hoogestraat |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Microbiology (medical) Opportunistic infection Septic shock opportunistic infection Immunocompromised hosts 030106 microbiology Case Report Human pathogen Biology Rhodococcus fascians biology.organism_classification medicine.disease Microbiology Clostridium Difficile Colitis post-transplant complication 03 medical and health sciences 030104 developmental biology Hepatic medicine Rhodococcus equi Pathogen Rhodococcus |
Zdroj: | JMM Case Reports |
ISSN: | 2053-3721 |
Popis: | Introduction: Rhodococcus spp. have been implicated in a variety of infections in immunocompromised and immunocompetent hosts. Rhodococcus equi is responsible for the majority of reported cases, but Rhodococcus erythropolis, Rhodococcusgordoniae and Rhodococcusruber infections have been described. There are no prior reports of human infection with Rhodococcus fascians. Case presentation: We describe the unexpected finding of R. fascians in liver lesions incidentally noted at autopsy in an immunosuppressed patient status after bone-marrow transplant for acute lymphoblastic leukaemia who died of unrelated causes (septic shock due to Clostridium difficile colitis). At autopsy, an otherwise unremarkable liver contained several dozen well-demarcated sclerotic-appearing lesions measuring 0.1–0.3 cm in size. The absence of other bacterial or fungal DNA in the setting of histologically visible organisms argues against its presence as a contaminant and raises the consideration that R. fascians represents a human pathogen for the immunocompromised. Conclusion: Whether it represents the sole infectious agent responsible for the miliary lesions or a partially treated co-infection is impossible to determine, but our finding continues to reinforce the importance of molecular techniques in associating organisms with sites of infection and optimizing treatment of infectious diseases. |
Databáze: | OpenAIRE |
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