Predictors of High-Grade Ventricular Arrhythmias in Patients Referred for the Coronary Angiography
| Autor: | Lykasova Ea, Vizner Lr, G V Kolunin, Krinochkin Dv, E A Gorbatenko, Iurkina IuA, Kuznetsov Va, Todosiĭchuk Vv, Nokhrina OIu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Coronary angiography medicine.medical_specialty Diastole Coronary Angiography Risk Assessment Severity of Illness Index Sudden cardiac death Ventricular Dysfunction Left Predictive Value of Tests Risk Factors Internal medicine medicine Humans In patient Heart Aneurysm Ejection fraction business.industry Age Factors Thrombosis Odds ratio Middle Aged medicine.disease Ventricular Premature Complexes Confidence interval Siberia Death Sudden Cardiac Heart failure Heart Function Tests Electrocardiography Ambulatory Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Kardiologiia. :44-48 |
| ISSN: | 0022-9040 |
| Popis: | Ventricular arrhythmias (VA) are still the leading cause of sudden cardiac death (SCD). Therefore identification of predictors of high-grade (hg) VA and stratification of risk of fatal events remain important problems of cardiology. We analyzed data of 993 patients with and without hgVA according to 24 hours Holter monitoring referred for the coronary angiography. Patients with hgVA were older (57.2 ± 8.4 vs. 54.9 ± 8.3 years, p = 0.001), had lower left ventricular ejection fraction (LVEF) (51.6 ± 11.2 vs. 58.4 ± 7.6%, p < 0.001) and larger extent of LV wall motion abnormalities (10.8 ± 15.7% vs. 5.5 ± 10.9%, p = 0.001). Patients with hgVA more often had LV aneurysms and thrombi. These patients also had significantly greater LV end diastolic diameter (54.3 ± 7.4 vs. 49.9 ± 4.7 mm, p < 0.001), and more often had NYHA class III-IV chronic heart failure (28.1 vs. 15.5%, p < 0.001). According to multivariate analysis hgVA were independently associated with age, LV dilation and reduced LVEF (specificity and sensitivity of a mathematical model for prediction of hgVA were 78 and 49.5%, respectively). Each subsequent year of life increased risk of having hgVA by 1.2% (odds ratio [OR] 1.01; 95% confidence interval [CI] 1.01-1.05, p = 0.002), while 1 mm increase of LV size elevated risk of VA by 4.2% (OR 1.08; 95% CI 1.04-1.13, p < 0.001), and 1% lowering of LVEF increased risk of VA by 7% (OR 0.95; 95% CI 0.92-0.98, p < 0.001). |
| Databáze: | OpenAIRE |
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