Aniracetam and DNQX affect the acquisition of rapid tolerance to ethanol in mice
| Autor: | Daniel Rial, Gina Struffaldi Morato, Reinaldo N. Takahashi |
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| Rok vydání: | 2008 |
| Předmět: |
Agonist
medicine.drug_class Clinical Biochemistry Glutamic Acid Kainate receptor AMPA receptor Pharmacology Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Mice Receptors Kainic Acid Drug tolerance Quinoxalines DNQX medicine Animals Receptors AMPA Neurotransmitter Postural Balance Biological Psychiatry Nootropic Agents Ethanol Central Nervous System Depressants Drug Tolerance Pyrrolidinones Aniracetam chemistry Competitive antagonist Female Excitatory Amino Acid Antagonists Psychomotor Performance medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 92(1) |
| ISSN: | 0091-3057 |
| Popis: | Several studies have emphasized the role of learning in the development of rapid tolerance and have shown that glutamate-mediated neurotransmission plays an important role in this phenomenon. Since the AMPA/kainate receptor system is directly involved in plasticity mechanisms, the influence of this receptor system on rapid tolerance induced by ethanol was studied using the rotarod. In the first experiment, mice were pretreated with aniracetam, an agonist of AMPA/kainate receptors, 30 min before ethanol (2.75 g/kg; IP) treatment, and tested on the rotarod. After 24 h, the groups were tested on the rotarod under ethanol treatment. Aniracetam facilitated the acquisition of rapid tolerance to ethanol. In the second experiment, mice received DNQX, a competitive antagonist of the AMPA receptor, 30 min before ethanol treatment (3 g/kg) and submitted to the rotarod. This dose of ethanol produced tolerance per se. Groups were tested under ethanol treatment (1.75 g/kg) after 24 h. DNQX blocked rapid tolerance to ethanol. Using a similar protocol, the third experiment showed that DNQX blocked the aniracetam-induced facilitation of rapid tolerance to ethanol. Our results show that aniracetam facilitates whereas DNQX blocks ethanol tolerance, suggesting that the non-NMDA receptors are involved in this phenomenon. |
| Databáze: | OpenAIRE |
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