The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study
| Autor: | Won Kee Lee, Hyun Hee Kwon, Jieun Kim, Won Suk Choi, Ki Tae Kwon, Shin Woo Kim, Jang Wook Sohn, Sook-In Jung, Yeon Sook Kim, Mi Suk Lee, Yu Mi Jo, Hyun-Ha Chang, Hye In Kim, Chisook Moon, Young Keun Kim, Hyun Ah Kim, Kyung-Hwa Park, Young Kyung Yoon, Hee Jung Yoon, Seong Yeol Ryu, Jian Hur |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Hepatitis B virus Time Factors Epidemiology Health Personnel 030106 microbiology Immunoglobulins medicine.disease_cause Hepatitis B antibody 03 medical and health sciences 0302 clinical medicine Internal medicine Occupational Exposure Republic of Korea medicine Infection control Humans 030212 general & internal medicine Seroconversion Hepatitis B Antibodies Retrospective Studies business.industry Health Policy Public Health Environmental and Occupational Health virus diseases Middle Aged Hepatitis B immunoglobulin Hepatitis B Vaccination Infectious Diseases Multicenter study Immunology Female Occupational exposure business Post-Exposure Prophylaxis |
| Zdroj: | American journal of infection control. 44(2) |
| ISSN: | 1527-3296 |
| Popis: | Background Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an important role in the prevention of HBV infections in health care workers (HCWs). We examined data concerning the acceptable duration between occupational exposure and administration of a hepatitis B immunoglobulin (HBIG) injection in an occupational clinical setting. Methods A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in 15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from the infection control records of each hospital. Results Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days. Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion to hepatitis b antibody positivity occurred. Conclusions For susceptible HCWs, HBIG administered between 24 hours and 7 days postexposure may be as effective as administration within 24 hours in preventing occupational HBV infection. |
| Databáze: | OpenAIRE |
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