Investigation of a dosage regimen for intravenous theophylline
| Autor: | Richard L. Yost, J. Daniel Robinson, Eloise M. Harman, Marshall C. Hughey |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
business.industry Serum concentration Pharmacology Middle Aged 030226 pharmacology & pharmacy Asthma Drug Administration Schedule 03 medical and health sciences Regimen Kinetics 0302 clinical medicine Theophylline 030220 oncology & carcinogenesis Anesthesia Injections Intravenous medicine Humans Pharmacology (medical) Infusions Parenteral General Pharmacology Toxicology and Pharmaceutics business medicine.drug Half-Life |
| Zdroj: | Drug intelligenceclinical pharmacy. 16(4) |
| ISSN: | 0012-6578 |
| Popis: | A study was designed to evaluate the validity of the dosage guidelines for theophylline recommended by Hendeles and Weinberger. A total of seven asthmatic smokers and non-smokers were entered and studied. Theophylline serum concentrations were determined prior to the start of therapy and at intervals following initiation of an infusion. The mean theophylline concentration attained for all subjects was 10 μg/ml, however, five of the six patients completing the study did not achieve the predicted serum theophylline concentration. Further study of higher dosage designed to achieve a concentration of 12 μg/ml is suggested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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