Hippocampal asymmetry in exploratory behavior to vasoactive intestinal polypeptide
| Autor: | Alexandar Ternianov, Margarita Ivanova, Iren Belcheva, Negrin Negrev, S. Belcheva, Roman Tashev |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Microinjections Physiology Central nervous system Vasoactive intestinal peptide Hippocampal formation Hippocampus Biochemistry Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Animals Hippocampus (mythology) Rats Wistar Injections Intraventricular Dose-Response Relationship Drug business.industry Low dose Rats medicine.anatomical_structure Exploratory Behavior business hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide |
| Zdroj: | Peptides. 29:940-947 |
| ISSN: | 0196-9781 |
| Popis: | The effects of vasoactive intestinal polypeptide (VIP) microinjected uni- or bilaterally into the CA1 hippocampal area of male Wistar rats at a dose of 10, 50 and 100 ng on exploratory behavior were examined. VIP microinjected bilaterally at a high dose (100 ng) significantly decreased the horizontal movements, while at low doses (10 and 50 ng) had no effect on the exploratory activity. Microinjections of VIP into the left hippocampal CA1 area at doses 50 and 100 ng suppressed the exploratory activity, while right-side VIP administration at a dose 100 ng significantly increased horizontal movements compared to the respective controls. Vertical activity was stimulated only by VIP administered into the right hippocampal CA1 area at the three doses used. Neither bilateral nor left injections of VIP induced changes in the vertical movements. The main finding was the presence of hippocampal asymmetry in exploratory behavior to unilateral microinjections of VIP depending on the dose and the microinjected hemisphere. |
| Databáze: | OpenAIRE |
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