Does the cognitive architecture of simplex and multiplex ASD families differ?

Autor: Catharina A. Hartman, Nanda Rommelse, Anoek M. Oerlemans, Barbara Franke, Jan K. Buitelaar
Přispěvatelé: Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)
Rok vydání: 2015
Předmět:
Male
Proband
Autism Spectrum Disorder
Intelligence
AUTISM SPECTRUM DISORDERS
CHILDREN
behavioral disciplines and activities
Developmental psychology
Autism Spectrum Disorder (ASD)
QUOTIENT AQ
03 medical and health sciences
Cognition
0302 clinical medicine
PARENTS
Social cognition
mental disorders
Developmental and Educational Psychology
medicine
Humans
Family
0501 psychology and cognitive sciences
Child
Social Behavior
Family Characteristics
Original Paper
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
EXECUTIVE FUNCTION
Siblings
05 social sciences
PROFILES
Cognitive architecture
Executive functions
medicine.disease
Simplex-multiplex stratification
COMMON GENETIC-VARIANTS
DE-NOVO MUTATIONS
COMPREHENSIVE METAANALYSIS
Autism spectrum disorder
Case-Control Studies
Child
Preschool
RISK-FACTORS
Trait
Autism
Female
Unaffected siblings
Psychology
030217 neurology & neurosurgery
050104 developmental & child psychology
Zdroj: Journal of Autism and Developmental Disorders, 46(2), 489-501. SPRINGER/PLENUM PUBLISHERS
Journal of Autism and Developmental Disorders, 46, 489-501
Journal of Autism and Developmental Disorders
Journal of Autism and Developmental Disorders, 46, 2, pp. 489-501
ISSN: 1573-3432
0162-3257
DOI: 10.1007/s10803-015-2572-9
Popis: Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD. Electronic supplementary material The online version of this article (doi:10.1007/s10803-015-2572-9) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
Externí odkaz: