Infantile amnesia reflects a developmental critical period for hippocampal learning
| Autor: | Robert D. Blitzer, Alessio Travaglia, Reto Bisaz, Cristina M. Alberini, Eric S. Sweet |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Hippocampus Amnesia Engram Receptors N-Methyl-D-Aspartate Childhood amnesia 03 medical and health sciences 0302 clinical medicine Memory mental disorders medicine Animals Learning Rats Long-Evans Episodic memory Metabotropic glutamate receptor 5 Long-term memory General Neuroscience Brain-Derived Neurotrophic Factor 030104 developmental biology nervous system Memory consolidation Female medicine.symptom Nerve Net Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature neuroscience. 19(9) |
| ISSN: | 1546-1726 |
| Popis: | Episodic memories formed during the first postnatal period are rapidly forgotten, a phenomenon known as 'infantile amnesia'. In spite of this memory loss, early experiences influence adult behavior, raising the question of which mechanisms underlie infantile memories and amnesia. Here we show that in rats an experience learned during the infantile amnesia period is stored as a latent memory trace for a long time; indeed, a later reminder reinstates a robust, context-specific and long-lasting memory. The formation and storage of this latent memory requires the hippocampus, follows a sharp temporal boundary and occurs through mechanisms typical of developmental critical periods, including the expression switch of the NMDA receptor subunits from 2B to 2A, which is dependent on brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor 5 (mGluR5). Activating BDNF or mGluR5 after training rescues the infantile amnesia. Thus, early episodic memories are not lost but remain stored long term. These data suggest that the hippocampus undergoes a developmental critical period to become functionally competent. |
| Databáze: | OpenAIRE |
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