Antidiabetic effect of Ficus bengalensis aerial roots in experimental animals
| Autor: | Shikha Mehta, Rakesh Kumar Singh, Dolly Jaiswal, Geeta Watal, Prashant Kumar Rai |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Ficus Blood sugar Pharmacognosy Plant Roots Streptozocin Diabetes Mellitus Experimental Lethal Dose 50 Drug Discovery medicine Animals Hypoglycemic Agents Rats Wistar Medicinal plants Glycemic Pharmacology Glucose tolerance test Dose-Response Relationship Drug biology medicine.diagnostic_test Traditional medicine Plant Extracts business.industry Glucose Tolerance Test biology.organism_classification Effective dose (pharmacology) Rats Female business Glipizide medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 123:110-114 |
| ISSN: | 0378-8741 |
| Popis: | Ethnopharmacological relevance Herbal preparations of Ficus bengalensis had been considered as effective, economical and safe ethnomedicines for various ailments in Indian traditional system of medicine. Aim of study The present study was aimed to explore scientifically the antidiabetic potential of Ficus bengalensis aerial roots as its bark had already been reported to possess antidiabetic efficacy. Materials and methods Effect of variable doses of aqueous extract of Ficus bengalensis aerial roots on blood glucose level (BGL) of normal-, sub- and mild-diabetic models have been studied and the results were compared with the reference drug Glipizide and elemental Mg and Ca intake as glycemic elements. Results The dose of 300 mg kg −1 showed the maximum fall of 43.8 and 40.7% in BGL during FBG and glucose tolerance test (GTT) studies of normal rats, respectively. The same dose showed a marked reduction in BGL of 54.3% in sub- and 51.7% in mild-diabetic rats during GTT. The concentration of Mg (1.02%) and Ca (0.85%) identified through laser induced breakdown spectroscopy (LIBS) in the most effective dose could be responsible for this high percentage fall in BGL as they take part in glucose metabolism. Conclusion The hypoglycemic effect in normoglycemic and antidiabetic effect in sub- and mild-diabetic models of aqueous extract of aerial roots of Ficus bengalensis are due to the presence of these glycemic elements in high concentration with respect to other elements. |
| Databáze: | OpenAIRE |
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