Red cell differential width (RDW) as a predictor of survival outcomes with palliative and adjuvant chemotherapy for metastatic penile cancer
| Autor: | Wing K Liu, Alison Tree, Reena Patel, Nick Watkin, Benjamin Ayres, Mehran Afshar, Lisa Pickering, Louise English |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Erythrocyte Indices Male 0301 basic medicine Nephrology Oncology medicine.medical_specialty Urology medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Renal cell carcinoma Internal medicine medicine Humans Penile cancer Survival outcomes Neoplasm Metastasis Correlation of Data Penile Neoplasms Aged Retrospective Studies Aged 80 and over Chemotherapy Urology - Original Paper business.industry Palliative Care Hazard ratio Red blood cell distribution width Biomarker Middle Aged Prognosis medicine.disease Survival Rate Log-rank test 030104 developmental biology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Cohort Red cell differential width business |
| Zdroj: | International Urology and Nephrology |
| ISSN: | 1573-2584 0301-1623 |
| DOI: | 10.1007/s11255-020-02565-0 |
| Popis: | Purpose Red cell distribution width (RDW) measures red cells’ size variability. Metastatic penile cancer displays poor chemotherapy response. As no validated prognostic predictor exists, we investigated whether RDW correlates independently with survival outcomes in metastatic penile cancer treated by chemotherapy. Methods Electronic chemotherapy files of patients with metastatic penile cancer (M1 or N3) from a large academic supra-regional centre were retrospectively analysed between 2005 and 2018. Patients were stratified into RDW > 13.9% and Results 58 patients were analysed. The RDW-high group (n = 31) had a poorer survival than the RDW-low group (n = 27). Median overall survival (mOS) in all patients was 19.0 months (95% CI 13.1–24.9). mOS for RDW-high was 15.0 months (95% CI 10.1–19.9) and 37.0 months (95% CI 32.3–43.1) for RDW-low. Kaplan–Meier curves showed a clear disparity in survival (log rank p = 0.025). Cox proportional hazard ratio for death, corrected for T-stage, grade, age and deprivation score was 0.43 (p = 0.04). Sub-analysis of the M1 patients showed mOS in RDW-high of 17 m (95% CI 11.6–22.4) vs. NR; HR for death of 0.42. N3 patients’ mOS in RDW-high cohort was 30 months (95% CI 4.5–55.9) vs. 13 months (95% CI 1.8–24.2) in RDW-low; HR for death was 0.30. Conclusion RDW correlates independently with survival outcomes in metastatic penile cancer and may act as a potential predictor of survival outcomes for patients with metastatic penile cancer receiving chemotherapy. |
| Databáze: | OpenAIRE |
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