Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma
| Autor: | D. E. Onions, Ruth F. Jarrett, A. Edna Dewar, A. S. Krajewski, Sarah Gledhill |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Genotype medicine.drug_class Context (language use) Biology Gene Rearrangement T-Lymphocyte Monoclonal antibody Pathology and Forensic Medicine Diagnosis Differential immune system diseases hemic and lymphatic diseases medicine Humans Aged Aged 80 and over Gene Rearrangement Genes Immunoglobulin Lymphoma Non-Hodgkin Gene rearrangement Middle Aged medicine.disease Hodgkin Disease Non-Hodgkin's lymphoma Lymphoma biology.protein Female Differential diagnosis Antibody DNA Probes Immunoglobulin Gene Rearrangement |
| Zdroj: | The Journal of Pathology. 161:245-254 |
| ISSN: | 1096-9896 0022-3417 |
| DOI: | 10.1002/path.1711610312 |
| Popis: | The results of genotypic analysis of 29 cases of malignant lymphoma are reported and the application of this technique for differentiating between Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) is evaluated. Five cases with a differential diagnosis which included HD and NHL were analysed. These results are compared with those obtained for six B-cell NHLs, nine T-cell NHLs, and nine cases of HD. This report suggests that gene rearrangement analysis is useful in some cases in which the differential diagnoses includes HD and NHL as the absence of gene rearrangements is more consistent with a diagnosis of HD than of NHL. Two monoclonal antibodies reactive with the variable region of the T-cell receptor β-chain and molecular probes to the relevant variable region genes were used to assist in the diagnosis of T-cell lymphoma. This report confirms that genotypic analysis is useful diagnostically when the results are assessed in the context of the histopathological findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text