Perturbation of monocyte subsets in iron-deficient children – a shift to a pro-inflammatory state?

Autor: Beauty Sarkar, Richa Gupta, Nimisha Dhankar, Shyam Lata Jain, Shramana Mandal
Rok vydání: 2021
Předmět:
Zdroj: Allergologia et Immunopathologia. 49:42-47
ISSN: 0301-0546
DOI: 10.15586/aei.v49i6.91
Popis: Background: Iron deficiency anemia (IDA) is the most prevalent micronutrient deficiency in preschool children in developing countries including India. IDA is associated with immune perturbation, which is reflected in greater frequency of infections in these children. Recent research has shown three distinct monocyte subsets with distinct functions linked to infectious, inflammatory, and autoimmune diseases. These subsets have not been studied in chil-dren with IDA. Objective: The aim of the study was to assess the percentage of monocyte population and the three subset populations in children with IDA and to compare the data with age-matched healthy controls. Methods: Venous blood samples (5 mL) from 40 IDA children and 20 controls were collected after taking informed consent. Monocyte subpopulations were compared across the two groups. The outcome variables were calculated using Students Independent t-test or Mann– Whitney U test. P value of
Databáze: OpenAIRE