RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4
| Autor: | I. G. Sipes, G. A. Burton, D. Belsito, Yoshiki Tokura, W. Dekant, Magnus Bruze, M. Date, J. Buschmann, L. Jones, G. Sullivan, T. M. Penning, J. Romine, H. Moustakas, I. Lee, Allison D. Fryer, M. Lavelle, S. Biserta, D. Selechnik, Y. Thakkar, Maria Lúcia Zaidan Dagli, Terry W Schultz, M. Kumar, M. Na, S. Gadhia, D. C. Liebler, G. Ritacco, C. Deodhar, K. Joshi, A.M. Api, F. Siddiqi, A. Lapczynski, M. A. Cancellieri, D. Botelho, N. Sadekar |
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| Rok vydání: | 2021 |
| Předmět: |
Endpoint Determination
TOXICOLOGIA AMBIENTAL Vis spectra Pharmacology Toxicology medicine.disease_cause Risk Assessment Heptanes 03 medical and health sciences 0404 agricultural biotechnology medicine Animals Humans Sulfhydryl Compounds 030304 developmental biology 0303 health sciences No-Observed-Adverse-Effect Level Bacteria business.industry Skin sensitization 04 agricultural and veterinary sciences General Medicine Fragrance ingredient 040401 food science Perfume Consumer Product Safety Toxicity Odorants Phototoxicity Reproductive toxicity business Genotoxicity CAS Registry Number Food Science |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1873-6351 |
| Popis: | 1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are |
| Databáze: | OpenAIRE |
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