Anti-Inflammatory Effects ofInonotus obliquusin Colitis Induced by Dextran Sodium Sulfate
| Autor: | Se Young Choi, Yun Hui Jeon, Young Jun Jeoung, Chi Sun An, Beong Ou Lim, Jong Phil Bak, Sun Jin Hur |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Article Subject Lipopolysaccharide lcsh:Biotechnology Health Toxicology and Mutagenesis Anti-Inflammatory Agents lcsh:Medicine Administration Oral Biology behavioral disciplines and activities Microbiology Mice chemistry.chemical_compound lcsh:TP248.13-248.65 Genetics medicine Animals Cytotoxic T cell STAT1 Colitis Molecular Biology STAT6 Biological Products Basidiomycota lcsh:R Dextran Sulfate General Medicine biology.organism_classification medicine.disease Molecular biology Mice Inbred C57BL Treatment Outcome chemistry Apoptosis biology.protein Cytokines Molecular Medicine Inonotus obliquus Tumor necrosis factor alpha Research Article Biotechnology |
| Zdroj: | Journal of Biomedicine and Biotechnology Journal of Biomedicine and Biotechnology, Vol 2010 (2010) |
| ISSN: | 1110-7251 1110-7243 |
| Popis: | A total of 28 male BALB/c mice (average weight 20.7 ± 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B),Inonotus obliquus(IO) administration (C), and IO administration + induced colitis by DSS (D). IO treatment (C, D) decreased the expression of tumor necrosis factor (TNF)-αand signal transducers and activators of transcription (STAT)1 compared to those of the colitis induced group (B). The expressions of IL-4 and STAT6 were decreased in group D compared to the colitis induced group (B). The serum immunoglobulin (Ig)E level decreased in IO treatment groups (C, D) compared to no IO treatment groups (A and B) although there was no significant difference between the IO treatment groups. Extract from IO itself had a weak cytotoxic effect on murine macrophage cell line (RAW264.7 cells). Extract from IO inhibited lipopolysaccharide- (LPS-) induced, TNF-α, STAT1, pSTAT1, STAT6, and pSTAT6 production in RAW264.7 cells. |
| Databáze: | OpenAIRE |
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