The metabolic characteristics of susceptibility to wooden breast disease in chickens with high feed efficiency
| Autor: | Nan Zhou, Zhu Zhuo, Elisa Peripolli, Behnam Abasht, William R Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
animal structures Population Muscle disorder Biology Feed conversion ratio Pectoralis Muscles 03 medical and health sciences chemistry.chemical_compound Muscular Diseases Internal medicine medicine Animals Myopathy education Poultry Diseases 030304 developmental biology chemistry.chemical_classification 0303 health sciences education.field_of_study Glycogen Sequence Analysis RNA Fatty Acids digestive oral and skin physiology Pectoralis major muscle 0402 animal and dairy science Broiler Fatty acid 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science Endocrinology chemistry Animal Nutritional Physiological Phenomena Animal Science and Zoology medicine.symptom Transcriptome Chickens |
| Zdroj: | Poultry Science. 98:3246-3256 |
| ISSN: | 0032-5791 |
| Popis: | This study was conducted to characterize metabolic differences between high feed efficiency (HFE) and low feed efficiency (LFE) chickens to investigate why feed efficient chickens are more susceptible to muscle abnormalities such as wooden breast disease. Gene expression profiles were generated by RNA sequencing of pectoralis major muscle samples from 10 HFE and 13 LFE broiler chickens selected from a modern broiler population. Metabolism-associated differentially expressed genes were identified and interpreted by Ingenuity Pathway Analysis and literature mining. Our RNA-seq data indicate decreased glycolytic capacity, increased fatty acid uptake, mitochondrial oxidation of fatty acids, and several other metabolic alterations in the pectoralis major muscle of HFE chickens. We also quantified glycogen content of the pectoralis major muscle and found that the HFE chickens had a significantly (P ≤ 0.05) lower glycogen content. Collectively, this study indicates extensive metabolic differences in the pectoralis major muscle between HFE and LFE chickens and helps identify metabolic features of susceptibility to muscle disorders in modern broiler chickens. |
| Databáze: | OpenAIRE |
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