Sleep patterns and blood pressure variability in patients with pure autonomic failure
| Autor: | A. J. Man In 'T Veld, Joke H.M. Tulen, H.G. van Steenis, K. Mechelse |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Neurology Hemodynamics Blood Pressure Hypotension Orthostatic Atrophy Diabetes mellitus medicine Humans Pure autonomic failure Aged Aged 80 and over Endocrine and Autonomic Systems business.industry Respiration Electroencephalography Middle Aged medicine.disease Sleep in non-human animals Electrooculography Blood pressure Autonomic Nervous System Diseases Anesthesia Female Neurology (clinical) Sleep onset business Sleep |
| Zdroj: | Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 1(4) |
| ISSN: | 0959-9851 |
| Popis: | Sleep patterns and 24-h blood pressure variability were studied in four female patients (age range: 56-82 years) with pure autonomic failure. All patients had severe symptomatic postural hypotension, without neurological deficits. In these patients the following patterns were observed: (i) a reversed diurnal blood pressure pattern, with the highest values observed at sleep onset; (ii) a prolonged sleep latency and increased amount of stage 3 sleep; (iii) difficulty with getting up after awakening in the morning, due to severe postural hypotension; (iv) an absence of prominent respiratory abnormalities during sleep; and (v) a dissociation between respiratory and haemodynamic findings. It is concluded that isolated deficiency of presumed postganglionic autonomic function influences sleep architecture, probably through absence of buffering of diurnal haemodynamic alterations, such as by postural hypotension and its consequences for body fluid volume regulation. This may be of relevance when sleep patterns are studied in other types of autonomic failure with postural hypotension involving central or preganglionic lesions, as in patients with the Shy-Drager syndrome or multiple system atrophy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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