Early State Research on Antifungal Natural Products
| Autor: | Melyssa Negri, Isis Regina Grenier Capoci, Cristiane Suemi Shinobu-Mesquita, Erika Seki Kioshima, Tânia Pereira Salci, Terezinha Inez Estivalet Svidzinski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Antifungal
Drug Antifungal Agents extracts medicine.drug_class natural products media_common.quotation_subject Antifungal drug Pharmaceutical Science Review Biology Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery medicine Animals Humans Physical and Theoretical Chemistry Medicinal plants essential oils media_common Biological Products business.industry Research Organic Chemistry History 20th Century Antimicrobial Biotechnology Chemistry (miscellaneous) Plant species Molecular Medicine fungi Low resistance business antifungal |
| Zdroj: | Molecules, Vol 19, Iss 3, Pp 2925-2956 (2014) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to the rising number of immunocompromised patients. However, the available antifungal therapeutic arsenal is limited, and the development of new drugs has been slow. Therefore, the search for alternative drugs with low resistance rates and fewer side effects remains a major challenge. Plants produce a variety of medicinal components that can inhibit pathogen growth. Studies of plant species have been conducted to evaluate the characteristics of natural drug products, including their sustainability, affordability, and antimicrobial activity. A considerable number of studies of medicinal plants and alternative compounds, such as secondary metabolites, phenolic compounds, essential oils and extracts, have been performed. Thus, this review discusses the history of the antifungal arsenal, surveys natural products with potential antifungal activity, discusses strategies to develop derivatives of natural products, and presents perspectives on the development of novel antifungal drug candidates. |
| Databáze: | OpenAIRE |
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