Association Between Secretoglobin Family 3A Member 2 (SCGB3A2) Gene Polymorphisms and Asthma in a Korean Population
| Autor: | Ju Yeon Ban, Su Kang Kim, Hee-Jae Jung, Joo-Ho Chung, Hosik Seok, Hae Jeong Park, Kyuup Han, Beom-Joon Lee, Kwan-Il Kim, Sang Wook Kang, Jinju Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Single-nucleotide polymorphism Secretoglobins Polymorphism Single Nucleotide Association 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Internal medicine Genotype Republic of Korea medicine Odds Ratio SNP Humans Genetic Predisposition to Disease Promoter Regions Genetic Allele frequency Molecular Biology Genetic Association Studies Asthma Polymorphism Genetic business.industry Case-control study Secretoglobin family 3A member 2 General Medicine Odds ratio Middle Aged medicine.disease 030104 developmental biology 030228 respiratory system Case-Control Studies Female business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | BACKGROUND Secretoglobin family 3A member 2 (SCGB3A2) plays an important role in secreting lung surfactant protein, which is a downstream target of thyroid transcription factor. MATERIAL AND METHODS We investigated whether single-nucleotide polymorphisms (SNPs) of SCGB3A2 gene contribute to susceptibility to asthma. To explore this possible association, 2 promoter SNPs (rs6882292, 659 G/A and rs1368408, -112 G/A) and missense SNP (rs151333009, stop codon) were tested in SCGB3A2 gene in 101 asthma patients and 377 healthy control subjects. SNPStats was used to obtain odds ratio (OR), 95% confidence intervals (CI), and P value adjusted for age and sex as covariables. Logistic regression method in each model (dominant, recessive, and log-additive) was applied to analyze genetic data. RESULTS rs151333009 SNP showed a monomorphic genotype. Two promoter SNPs (rs6882292, -659 G/A and rs1368408, -112 G/A) showed significant association with asthma (rs6882292, OR=2.66, 95% CI=1.42-5.01, p=0.0033 in dominant model, OR=2.45, 95% CI=1.33-4.54, p=0.0055 in log-additive model; rs1368408, OR=1.59, 95% CI=1.02-2.49, p=0.041 in dominant model, OR=3.02, 95% CI=1.15-7.90, p=0.03 in recessive model, OR=1.63, 95% CI=1.63, 95% CI=1.12-2.37, p=0.012 in log-additive model). CONCLUSIONS These results suggest that the promoter SNPs (rs6882292 and rs1368408) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population. |
| Databáze: | OpenAIRE |
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