The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation

Autor: Ranganathan Arunkumar, Paul S. Bernstein
Rok vydání: 2020
Předmět:
0301 basic medicine
Lutein
retina
Visual acuity
antioxidant
meso-zeaxanthin
genetic structures
Physiology
030204 cardiovascular system & hematology
MacTel
macular telangiectasia type 2
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Medicine
ocular development
AMD
age-related macular degeneration
Carotenoid
chemistry.chemical_classification
GSTP1
glutathione S-transferase P1
ROP
retinopathy of prematurity
food and beverages
Retinopathy of prematurity
MP
macular pigment
Zeaxanthin
nutrition
zeaxanthin
Meso-zeaxanthin
medicine.symptom
Thematic Review Series: Seeing 2020: Lipids and Lipid-Soluble Molecules in the Eye
RPE
retinal pigment epithelium
ocular health
BCO2
β-carotene-oxygenase 2
L
lutein
QD415-436
03 medical and health sciences
RRS
resonance Raman spectroscopy
MZ
meso-zeaxanthin
age-related macular degeneration
RPE65
retinoid isomerase
lutein
BCO1
β-caroteneoxygenase 1
business.industry
Thematic Review Series
Cell Biology
Macular degeneration
medicine.disease
eye diseases
030104 developmental biology
RPE65
chemistry
Z
zeaxanthin
Macular Pigment
business
Zdroj: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100038-(2021)
ISSN: 1539-7262
Popis: Since the publication of the Age-Related Eye Disease Study 2 (AREDS2) in 2013, the macular pigment carotenoids lutein (L) and zeaxanthin (Z) have become well known to both the eye care community and the public. It is a fascinating aspect of evolution that primates have repurposed photoprotective pigments and binding proteins from plants and insects to protect and enhance visual acuity. Moreover, utilization of these plant-derived nutrients has been widely embraced for preventing vision loss from age-related macular degeneration. More recently, there has been growing awareness that these nutrients can also play a role in improving visual performance in adults. On the other hand, the potential benefits of L and Z supplementation at very young ages have been underappreciated. In this review, we examine the biochemical mechanisms and supportive data for L and Z supplementation throughout the lifespan, with particular emphasis on prenatal supplementation. We propose that prenatal nutritional recommendations may aim at improving maternal and infant carotenoid status. Prenatal supplementation with L and Z might enhance infant visual development and performance and may even prevent retinopathy of prematurity, possibilities that should be examined in future clinical studies.
Databáze: OpenAIRE
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