Chemical ligation from O-acyl isopeptides via 8- and 11-membered cyclic transition states
| Autor: | Mirna El-Katib, Khalid A. Alamry, Alan R. Katritzky, Alexander A. Oliferenko, Mohamed Elagawany, Hadi M. Marwani, Siva S. Panda, Eray Çalɪşkan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Benzotriazole Chemistry Organic Chemistry Intermolecular force Peptide Tripeptide Combinatorial chemistry Transition state lcsh:QD241-441 Serine chemistry.chemical_compound lcsh:Organic chemistry lipids (amino acids peptides and proteins) Chemical ligation Threonine |
| Zdroj: | ARKIVOC, Vol 2014, Iss 4, Pp 91-106 (2014) |
| ISSN: | 1551-7012 |
| Popis: | Unprotected O-acylated serine and O-acylated threonine isopeptides have been synthesized, and their conversion to native tripeptides and tetrapeptides by O- to N-terminus transfer investigated. Ligations involving 8- and 11-membered cyclic transition states are shown experimentally and computationally to be more favorable than intermolecular cross-ligations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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