Occurrence and Toxicity of Disinfection Byproducts in European Drinking Waters in Relation with the HIWATE Epidemiology Study
| Autor: | Michael J. Plewa, A. Bruce McKague, Mark J. Nieuwenhuijsen, Wentai Luo, Clara H. Jeong, Vincent R. Siebert, Susan D. Richardson, Cristina M. Villanueva, Emma H. Goslan, Eric J. Daiber, Elena Righi, James F. Pankow, Sylvaine Cordier, Elizabeth D. Wagner, Lorne M. Isabelle, Sridevi Anduri, Susan C. Edwards, Manolis Kogevinas, Regina Grazuleviciene |
|---|---|
| Přispěvatelé: | IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, School of Water Science, Cranfield University, Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Public Health Sciences, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE) |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Cricetinae
disinfection by-products pregnancy outcomes european union mammalian cell toxicity 010501 environmental sciences medicine.disease_cause 01 natural sciences MESH: Pregnancy MESH: Cricetulus MESH: Disinfection Pregnancy Cricetinae Mammalian cell Epidemiology Environmental monitoring MESH: Animals DBPs media_common 0303 health sciences Water contaminants Pregnancy Outcome 3. Good health Europe MESH: Water Pollutants Chemical MESH: Cell Survival [SDV.TOX]Life Sciences [q-bio]/Toxicology Environmental chemistry Toxicity cytotoxicity Female epidemiology MESH: Environmental Monitoring Environmental Monitoring medicine.medical_specialty Cell Survival CHO Cells Biology occurrence Article 03 medical and health sciences Cricetulus MESH: CHO Cells medicine Animals Humans Environmental Chemistry media_common.cataloged_instance European union Pregnancy outcomes 030304 developmental biology 0105 earth and related environmental sciences MESH: DNA Damage MESH: Humans HIWATE genotoxicity drinking water General Chemistry MESH: Pregnancy Outcome Disinfection disinfection byproducts MESH: Europe MESH: Female MESH: Drinking Water Water Pollutants Chemical Genotoxicity DNA Damage |
| Zdroj: | Environmental Science and Technology Environmental Science and Technology, American Chemical Society, 2012, 46 (21), pp.12120-8. ⟨10.1021/es3024226⟩ Environmental Science and Technology, 2012, 46 (21), pp.12120-8. ⟨10.1021/es3024226⟩ |
| ISSN: | 1520-5851 0013-936X |
| DOI: | 10.1021/es3024226 |
| Popis: | International audience; The HIWATE (Health Impacts of long-term exposure to disinfection byproducts in drinking WATEr) project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts (DBPs) in the European Union. The present study focused on the relationship of the occurrence and concentration of DBPs with in vitro mammalian cell toxicity. Eleven drinking water samples were collected from five European countries. Each sampling location corresponded with an epidemiological study for the HIWATE program. Over 90 DBPs were identified; the range in the number of DBPs and their levels reflected the diverse collection sites, different disinfection processes, and the different characteristics of the source waters. For each sampling site, chronic mammalian cell cytotoxicity correlated highly with the numbers of DBPs identified and the levels of DBP chemical classes. Although there was a clear difference in the genotoxic responses among the drinking waters, these data did not correlate as well with the chemical analyses. Thus, the agents responsible for the genomic DNA damage observed in the HIWATE samples may be due to unresolved associations of combinations of identified DBPs, unknown emerging DBPs that were not identified, or other toxic water contaminants. This study represents the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|