STAM-binding protein regulates melanoma metastasis through SLUG stabilization
| Autor: | Yoshihiro Hayakawa, Yusuke Iwakami, Kensuke Watanabe, Satoru Yokoyama |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell Survival Somatic cell Slug Biophysics Biology Biochemistry Deubiquitinating enzyme Metastasis Mice 03 medical and health sciences Cell Line Tumor medicine Animals Humans Neoplasm Invasiveness Neoplasm Metastasis Melanoma Molecular Biology STAM-Binding Protein Endosomal Sorting Complexes Required for Transport Protein Stability Mechanism (biology) Lysine Ubiquitination Cancer Cell Biology medicine.disease biology.organism_classification 030104 developmental biology Cancer research biology.protein Female Snail Family Transcription Factors Ubiquitin Thiolesterase |
| Zdroj: | Biochemical and Biophysical Research Communications. 507:484-488 |
| ISSN: | 0006-291X |
| Popis: | STAM-binding protein, STAMBP, is a JAMM-family deubiquitinating enzyme containing the microtubule-interacting/transport domain and STAM-binding domain. Although the biological importance of STAMBP in development has been recognized because the microcephaly-capillary malformation syndrome in human is caused by its somatic mutations, the role of STAMBP in cancer has not yet been determined. In this study, we demonstrate that STAMBP is a key molecule for regulating melanoma migration and invasion, but not survival, by knocking down STAMBP in vitro. STAMBP regulates SLUG expression through a post-transcriptional mechanism to control protein stability and further contributes to the in vivo metastatic potential of melanoma. Collectively, these results indicate the importance of STAMBP in melanoma metastasis by regulating SLUG. It is therefore a potential therapeutic target. |
| Databáze: | OpenAIRE |
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