The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
| Autor: | Karim C. El Kasmi, Linda K. Johnson, Jacob E. Friedman, Angelo D'Alessandro, Linda A. Barbour, Laurel L. Lenz, Teri L. Hernandez, Rachel C. Janssen, Christopher E. Mulligan, Kristine A. Kuhn, Sarah E. Clark, Dominick J. Lemas, Lyndsey Babcock, Daniel N. Frank, Taylor K. Soderborg, Nancy F. Krebs, Tiffany L. Weir, Bridget E. Young, Diana Ir |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Offspring Science General Physics and Astronomy Inflammation Gut flora General Biochemistry Genetics and Molecular Biology Childhood obesity 03 medical and health sciences 0302 clinical medicine Immunity parasitic diseases medicine lcsh:Science 2. Zero hunger Multidisciplinary Intestinal permeability biology business.industry Fatty liver General Chemistry medicine.disease biology.organism_classification 3. Good health 030104 developmental biology Immunology 030211 gastroenterology & hepatology lcsh:Q medicine.symptom business Dysbiosis |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| ISSN: | 2041-1723 |
| Popis: | Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant gut by microbes plays a critical role in establishing immunity and metabolic function. Here, we compare germ-free mice colonized with stool microbes (MB) from 2-week-old infants born to obese (Inf-ObMB) or normal-weight (Inf-NWMB) mothers. Inf-ObMB-colonized mice demonstrate increased hepatic gene expression for endoplasmic reticulum stress and innate immunity together with histological signs of periportal inflammation, a histological pattern more commonly reported in pediatric cases of NAFLD. Inf-ObMB mice show increased intestinal permeability, reduced macrophage phagocytosis, and dampened cytokine production suggestive of impaired macrophage function. Furthermore, exposure to a Western-style diet in Inf-ObMB mice promotes excess weight gain and accelerates NAFLD. Overall, these results provide functional evidence supporting a causative role of maternal obesity-associated infant dysbiosis in childhood obesity and NAFLD. |
| Databáze: | OpenAIRE |
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